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Vol:4 Issue:8 Number:1 ISSN#:2564-2537
ACE Report #7802
Ace Report Cover Osteoarthritis

No benefit to hyaluronic acid over placebo for knee OA pain and function

How to Cite

OrthoEvidence. No benefit to hyaluronic acid over placebo for knee OA pain and function. ACE Report. 2015;4(8):1. Available from:

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

No difference between intra-articular injection of hyaluronic Acid and placebo for mild to moderate knee osteoarthritis: a randomized, controlled, double-blind trial.

J Arthroplasty. 2015 May;30(5):754-7.

Contributing Authors: W van der Weegen JA Wullems E Bos H Noten RA van Drumpt

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196 patients were randomized to receive either hyaluronic acid (HA) or a placebo in knee osteoarthritis (OA) treatment. HA was compared to placebo to test the efficacy in reduction of pain and function. Results of this study found no significant benefit of HA treatment over placebo for visual analogue score, Western Ontario and McMaster Universities Arthritis Index (WOMAC), or knee flexion. Howeve...

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