ACE Report #7626
Ace Report Cover Arthroplasty

AAOS 2015: No difference between topical and intravenous tranexamic acid for TKA

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

The Effect of Topical Tranexamic Acid during Arthroplasty of the Knee on Blood Loss

Contributing Authors: JH May GR Rieser C Williams RJ Markert A Krishnamurthy RD Bauman M Lawless

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


131 patients undergoing total knee arthroplasty were randomized to receive tranexamic acid either topically, with 2mg injected intra-articularly following capsular closure, or 1 mg intravenously prior to tourniquet inflation and another 1mg prior to tourniquet deflation. Postoperative hemoglobin levels and cumulative blood loss were assessed for 3 days postoperatively, and length of stay, discharg...

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