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Volume:4 Issue:3 Number:24 ISSN#:2563-5476
Author Verified
RCT
ACE Report #7474
Ace Report Cover Metabolic Disorders

Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake


How to Cite

OrthoEvidence. Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake. ACE Report. 2015;4(3):24. Available from: https://myorthoevidene.com/AceReport/Report/7474

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.

Am J Clin Nutr. 2014 Dec;100(6):1578-86.

Contributing Authors: JP van Wijngaarden KM Swart AW Enneman RA Dhonukshe-Rutten SC van Dijk AC Ham EM Brouwer-Brolsma NL van der Zwaluw E Sohl JB van Meurs MC Zillikens NM van Schoor N van der Velde J Brug AG Uitterlinden P Lips LC de Groot

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Synopsis

2919 elderly hyperhomocysteinemic patients at risk for osteoporotic fractures were randomized to receive daily oral supplements containing 500 mg vitamin B-12, 400 mg folic acid and 600 IU of vitamin D3 or a placebo supplement containing only vitamin D3. The purpose of this study was to investigate whether the intake of vitamin B-12 and folic acid impacted the time to first osteoporotic fracture a...

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