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RCT
ACE Report #7429
Ace Report Cover Arthroplasty

Equivalent blood conservation with intra-articular and intravenous TXA in TKA


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Topical intra-articular compared with intravenous tranexamic Acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

Contributing Authors: E Gomez-Barrena M Ortega-Andreu NG Padilla-Eguiluz H Pérez-Chrzanowska R Figueredo-Zalve

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Synopsis

Seventy-eight patients scheduled for total knee arthroplasty were randomized to receive either intra-articular or intravenous administration of tranexamic acid to evaluate comparative efficacy between the two types. Transfusion rate, blood loss, and the incidence of thomboembolic complications were assessed perioperatively. Results demonstrated no significant differences between groups in any outc...

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