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Denosumab increases BMD and reduces bone turnover vs monthly oral bisphosphonate

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Ace Report Cover
December 2016

Denosumab increases BMD and reduces bone turnover vs monthly oral bisphosphonate

Vol: 5| Issue: 12| Number:43| ISSN#: 2564-2537
Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A

Denosumab significantly increases bone mineral density and reduces bone turnover compared with monthly oral ibandronate and risedronate in postmenopausal women who remained at higher risk for fracture despite previous suboptimal treatment with an oral bis

Osteoporos Int. 2014 Jul;25(7):1953-61. doi: 10.1007/s00198-014-2692-7. Epub 2014 Mar 28.

Contributing Authors:
JP Brown C Roux PR Ho MA Bolognese J Hall HG Bone S Bonnick JP van den Bergh I Ferreira P Dakin RB Wagman C Recknor

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Synopsis

A post hoc analysis was performed combining the data from two previously conducted randomized controlled trials (RCTs) in postmenopausal women (total of 1705 patients) with low adherence to a daily/weekly BP treatment who then transitioned to either denosumab or a monthly BP treatment (ibandronate and risedronate, respectively). This study aimed to compare bone mineral density and bone turnover ma...

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