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Denosumab increases BMD and reduces bone turnover vs monthly oral bisphosphonate
December 2016
Denosumab increases BMD and reduces bone turnover vs monthly oral bisphosphonate
Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A
Denosumab significantly increases bone mineral density and reduces bone turnover compared with monthly oral ibandronate and risedronate in postmenopausal women who remained at higher risk for fracture despite previous suboptimal treatment with an oral bis
Osteoporos Int. 2014 Jul;25(7):1953-61. doi: 10.1007/s00198-014-2692-7. Epub 2014 Mar 28.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
A post hoc analysis was performed combining the data from two previously conducted randomized controlled trials (RCTs) in postmenopausal women (total of 1705 patients) with low adherence to a daily/weekly BP treatment who then transitioned to either denosumab or a monthly BP treatment (ibandronate and risedronate, respectively). This study aimed to compare bone mineral density and bone turnover ma...
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