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Volume:3 Issue:10 Number:62 ISSN#:2563-5476
ACE Report #6707
Ace Report Cover General Orthopaedics

POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery

How to Cite

OrthoEvidence. POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery. ACE Report. 2014;3(10):62. Available from: https://myorthoevidence.com/AceReport/Report/6707

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Clonidine in patients undergoing noncardiac surgery

N Engl J Med. 2014 Apr 17;370(16):1504-13. doi: 10.1056/NEJMoa1401106. Epub 2014 Mar 31.

Contributing Authors: PJ Devereaux DI Sessler K Leslie A Kurz M Mrkobrada P Alonso-Coello JC Villar A Sigamani BM Biccard CS Meyhoff JL Parlow G Guyatt A Robinson AX Garg RN Rodseth F Botto G Lurati Buse D Xavier MT Chan M Tiboni D Cook PA Kumar P Forget

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10,010 patients with, or at risk for, major vascular disease, and undergoing non-cardiac surgery were randomized to receive either clonidine or placebo (both with and without aspirin) as part of the Perioperative Ischemic Evaluation 2 (POISE-2) trial. This report, Part 2, summarizes the data pertaining to the safety and efficacy of clonidine, while aspirin-related data is summarized in Part 1. Res...

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