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POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery
October 2014
POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Clonidine in patients undergoing noncardiac surgery
N Engl J Med. 2014 Apr 17;370(16):1504-13. doi: 10.1056/NEJMoa1401106. Epub 2014 Mar 31.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
10,010 patients with, or at risk for, major vascular disease, and undergoing non-cardiac surgery were randomized to receive either clonidine or placebo (both with and without aspirin) as part of the Perioperative Ischemic Evaluation 2 (POISE-2) trial. This report, Part 2, summarizes the data pertaining to the safety and efficacy of clonidine, while aspirin-related data is summarized in Part 1. Res...
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