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Volume:2 Issue:10 Number:61 ISSN#:2563-5476
RCT
ACE Report #6706
Ace Report Cover General Orthopaedics

POISE 2 (Part 1): The safety and efficacy of aspirin following non-cardiac surgery


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Aspirin in patients undergoing noncardiac surgery

N Engl J Med. 2014 Apr 17;370(16):1494-503. doi: 10.1056/NEJMoa1401105. Epub 2014 Mar 31

Contributing Authors: PJ Devereaux M Mrkobrada DI Sessler K Leslie P Alonso-Coello A Kurz JC Villar A Sigamani BM Biccard CS Meyhoff JL Parlow G Guyatt A Robinson AX Garg RN Rodseth F Botto G Lurati Buse D Xavier MT Chan M Tiboni D Cook PA Kumar P Forget

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Synopsis

10,010 patients with, or at risk for, major vascular disease, and undergoing non-cardiac surgery were randomized to receive either aspirin or placebo (both with and without clonidine) as part of the Perioperative Ischemic Evaluation 2 (POISE-2) trial. This report, Part 1, summarizes the data pertaining to the safety and efficacy of aspirin, while clonidine-related data is summarized in Part 2. Res...

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