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Lorazepam vs. Diazepam in the treatment of Pediatric Status Epilepticus

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Ace Report Cover
July 2014

Lorazepam vs. Diazepam in the treatment of Pediatric Status Epilepticus

Vol: 3| Issue: 7| Number:27| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Lorazepam vs Diazepam for Pediatric Status Epilepticus A Randomized Clinical Trial

JAMA. 2014 Apr 23-30;311(16):1652-60

Contributing Authors:
JM Chamberlain P Okada M Holsti P Mahajan KM Brown C Vance V Gonzalez R Lichenstein R Stanley DC Brousseau J Grubenhoff R Zemek DW Johnson TE Clemons J Baren (PECARN) Pediatric Emergency Care Applied Research Network

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Synopsis

Three hundred and ten patients, aged 3 months to 18 years, exhibiting tonic-clonic status epilepticus were randomized to determine a superior treatment between lorazepam and diazepam. Goals of treatment were cessation of status epilepticus by 10 minutes, without recurrence within 30 minutes. Patients were evaluated over 4 hours after treatment, and up to 24 hours, or until hospital discharge for ...

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