ACE Report #6061
Ace Report Cover Arthroplasty

AAOS: Tranexamic acid equally effective when administered topically & intravenously in TKA

Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Comparison of IV and topical tranexamic acid in total knee arthroplasty: a prospective randomized study

Contributing Authors: JN Patel J Spanyer LS Smith J Huang MR Yakkanti AL Malkani

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


85 patients with end stage knee arthritis scheduled to undergo total knee arthroplasty (TKA) were randomized to receive tranexamic acid (TXA) administered either topically or intravenously. The purpose of this study was to compare the efficacy and safety of these two treatment approaches. Results indicated that TXA when topically-applied, resulted in similar haemoglobin values, postoperative drain...

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