AAOS: IV tranexamic acid & aminocaproic acid on reducing blood loss in orthopaedic surgery
Efficacy of antifibrinolytics on surgical bleeding in orthopaedic surgery: a meta-analysis
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54 studies (comprising 59 randomized controlled trials with 3402 patients) were included in this meta-analysis comparing the use of either intravenous tranexamic acid (TXA) or intravenous epsilon aminocaproic acid (EACA) to placebo in reducing blood loss in orthopaedic surgery. TXA was observed to significantly reduce intraoperative, postoperative, and total blood loss while reducing transfusion r...
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