ACE Report #6060
Ace Report Cover General Orthopaedics

AAOS: IV tranexamic acid & aminocaproic acid on reducing blood loss in orthopaedic surgery

Study Type:Meta analysis
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Efficacy of antifibrinolytics on surgical bleeding in orthopaedic surgery: a meta-analysis

Contributing Authors: T Cheriyan SP Maier K Bianco K Slobodyanyuk FJ Schwab B Lonner TJ Errico

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


54 studies (comprising 59 randomized controlled trials with 3402 patients) were included in this meta-analysis comparing the use of either intravenous tranexamic acid (TXA) or intravenous epsilon aminocaproic acid (EACA) to placebo in reducing blood loss in orthopaedic surgery. TXA was observed to significantly reduce intraoperative, postoperative, and total blood loss while reducing transfusion r...

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