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RCT
ACE Report #6010
Ace Report Cover Tumour

Oral ibandronic acid inferior to IV zoledronic acid for metastatic breast cancer to bone


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Oral ibandronic acid versus intravenous zoledronic acid in treatment of bone metastases from breast cancer: a randomised, open label, non-inferiority phase 3 trial

Lancet Oncol. 2014 Jan;15(1):114-22. doi: 10.1016/S1470-2045(13)70539-4.

Contributing Authors: P Barrett-Lee A Casbard J Abraham K Hood R Coleman P Simmonds H Timmins D Wheatley R Grieve G Griffiths N Murray

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Synopsis

1404 patients with bone metastases from breast cancer were randomized to receive treatment with either oral ibandronic acid or intravenous zoledronic acid. The frequency and timing of skeletal-related events (SREs) was the primary non-inferiority endpoint. After 96 weeks of treatment, 50 mg of oral ibandronic acid given daily was inferior to 4 mg of intravenous zoledronic acid given every 4 weeks ...

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