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Fragility Index to aid in the interpretation of significant findings from RCTs
May 2014
Fragility Index to aid in the interpretation of significant findings from RCTs
Study Type:Non-Clinical
OE Level Evidence:N/A
Journal Level of Evidence:N/A
The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index
J Clin Epidemiol. 2014 Feb 5. pii: S0895-4356(13)00466-6. doi: 10.1016/j.jclinepi.2013.10.019Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
While P-values in clinical studies are an easy method to denote statistical significance, the interpretation of significant findings can be somewhat skewed. The Fragility Index is a newly developed metric that complements p-values and confidence intervals. It is calculated by adding consecutive events to a significant dichotomous finding until the result is no longer significant. The number of eve...
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