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Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients
January 2014
Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.
Osteoarthritis Cartilage. 2013 Sep;21(9):1400-8Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
100 patients enrolled in this study to determine the effects of specific nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis of the knee. High and low doses of celecoxib, diclofenac and ibuprofen were administered for 2 weeks prior to TKA operation. The results taken just before the operation suggest that Interleukin-6 (IL-6), tumor necrosis factor-alpha and vascular endothelia...
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