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Ankle arthrodesis: rhPDGF-BB/TCP is an effective and safe alternative to autograft

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Ace Report Cover
October 2013

Ankle arthrodesis: rhPDGF-BB/TCP is an effective and safe alternative to autograft

Vol: 2| Issue: 9| Number:3| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Recombinant Human Platelet-Derived Growth Factor-BB and Beta-Tricalcium Phosphate (rhPDGF-BB/B-TCP): An Alternative to Autogenous Bone Graft

J Bone Joint Surg Am. 2013 Jul 3;95(13):1184-92. doi: 10.2106/JBJS.K.01422

Contributing Authors:
CW Digiovanni SS Lin JF Baumhauer T Daniels A Younger M Glazebrook J Anderson R Anderson P Evangelista SE Lynch North American Orthopedic Foot Ankle Study Group

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Synopsis

Four hundred and thirty four patients in need of either an ankle or hindfoot arthrodesis were randomized to undergo the procedure using either the recombinant human (rh) PDGF-BB/TCP or autograft as bone fusion promoters to determine the non-inferiority of rhPDGF-BB/TCP. Results indicated that rhPDGF-BB/TCP proved to be non-inferior to autograft with respect to fusion rates, clinical union, radiogr...

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