Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Volume:3 Issue:2 Number:15 ISSN#:2564-2537
Author Verified
ACE Report #5244
Ace Report Cover Tumour

Denosumab noninferior to zoledronic acid in the treatment of bone metastasis

How to Cite

OrthoEvidence. Denosumab noninferior to zoledronic acid in the treatment of bone metastasis. ACE Report. 2014;3(2):15. Available from: https://myorthoevidence.com/AceReport/Report/5244

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma

J Clin Oncol. 2011 Mar 20;29(9):1125-32. doi: 10.1200/JCO.2010.31.3304. Epub 2011 Feb 22

Contributing Authors: DH Henry L Costa F Goldwasser V Hirsh V Hungria J Prausova GV Scagliotti H Sleeboom A Spencer S Vadhan-Raj R von Moos W Willenbacher PJ Woll J Wang Q Jiang S Jun R Dansey H Yeh

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here


1,779 patients with solid tumours (except breast and prostate) or myeloma, as well as at least 1 bone metastasis or osteolytic lesion as confirmed by radiographic imaging were randomized to receive either monthly subcutaneous injections of denosumab or intravenous administration of zoledronic acid to compare the efficacy and safety of these two treatments. Results at 34 months indicated that denos...

To view the full report, start your 30-day free trial today

No credit card required

JOIN Forgot Password?

Not sure if you want to join OrthoEvidence?

Access this report without an Account.

Success, an email containing a link to access this report has been sent to your inbox.

CME Image

Continuing Medical Education Credits

You could be earning 0.5 CME credits for each report you read.

For Reprints and Permissions, click here

Please Login or Join to leave comments.