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Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion
August 2014
Osteogenic protein-1 is safe and effective in the treatment of tibial nonunion
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions
J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
122 patients with 124 tibial nonunions were treated with intramedullary nailing and randomized to receive a fresh bone autograft or recombinant human osteogenic protein-1 (rhOP-1). Patients were assessed for severity of pain at the fracture site, the ability to walk with full weightbearing, need for surgical re-treatment of the nonunion, radiographic evaluation of healing, and physician satisfacti...
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