Ewing sarcoma treatment: assessment of cyclophosphamide and etoposide on survival rates

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients-

J Clin Oncol. 2008 Sep 20;26(27):4385-93. doi: 10.1200/JCO.2008.16.5720

Contributing Authors: M Paulussen AW Craft I Lewis A Hackshaw C Douglas J Dunst A Schuck W Winkelmann G Köhler C Poremba A Zoubek R Ladenstein H van den Berg A Hunold A Cassoni D Spooner R Grimer J Whelan A McTiernan H Jürgens European Intergroup Cooperativ

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Synopsis

647 patients with localized Ewing sarcoma were sorted into two risk groups based on the stage and tumour volume. Patients were allocated to the standard-risk (SR) group if their localized tumours were less than 100 mL in volume. Patients with localized tumours greater than 100 mL or with metastatic disease were allocated to the high-risk (HR) group. The 155 SR patients were then randomized to rece...