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ACE Report #5101
Ace Report Cover Tumour

Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients

Eur J Cancer. 2007 Mar;43(4):752-61. Epub 2007 Jan 30

Contributing Authors: MC Le Deley JM Guinebretiere JC Gentet H Pacquement F Pichon P Marec-Berard N Entz-Werle C Schmitt L Brugieres D Vanel N Dupouy MD Tabone C Kalifa (SFOP) Societe Francaise d'Oncologie Pediatrique

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Synopsis

234 patients with nonmetastatic osteosarcoma were randomized to preoperative chemotherapy of high-dose methotrexate with either doxorubicin or with etoposide and ifosfamide. After a median of 77-month follow-up, patients who had received the etoposide-ifosfamide regimen exhibited a larger percentage of good histologic response. Three- and 5-year overall and event-free survival rates were significa...

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