MTP-PE added to chemotherapy did not improve outcomes in metastatic osteosarcoma patients

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group

Cancer. 2009 Nov 15;115(22):5339-48. doi: 10.1002/cncr.24566

Contributing Authors: AJ Chou ES Kleinerman MD Krailo Z Chen DL Betcher JH Healey Conrad EU ML Nieder MA Weiner RJ Wells RB Womer PA Meyers Children's Oncology Group

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Synopsis

91 patients with metastatic osteosarcoma were randomized to receive a 3-drug treatment of chemotherapy (cisplatin, doxorubicin, and high-dose methotrexate) with or without ifosfamide. Within each group patients were further randomized to either receive liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) or not to determine whether the addition of liposomal MTP-PE to chemotherapy was eff...