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RCT
ACE Report #5096
Ace Report Cover Tumour

Ewing sarcoma: Similar survival rates with intensified dose regimen of VDC/IE


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study

J Clin Oncol. 2009 May 20;27(15):2536-41. doi: 10.1200/JCO.2008.19.1478. Epub 2009 Apr 6

Contributing Authors: L Granowetter R Womer M Devidas M Krailo C Wang M Bernstein N Marina P Leavey M Gebhardt J Healey RC Shamberger A Goorin J Miser J Meyer CA Arndt S Sailer K Marcus E Perlman P Dickman HE Grier

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Synopsis

478 patients under the age of 30, diagnosed with non-metastatic ESFT (or the Ewing sarcoma family of tumours), were randomized to either a standard or intensified dose regimen of vincristine, doxorubicin, and cyclophosphamide (VDC) along with ifosfamide and etoposide (IE) to assess the 5-year event-free and overall survival rates between groups. Results indicated that there was no significant diff...

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