Interval-compressed chemotherapy effective in treatment of localized Ewing sarcoma

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group

J Clin Oncol. 2012 Nov 20;30(33):4148-54. doi: 10.1200/JCO.2011.41.5703. Epub 2012 Oct 22

Contributing Authors: RB Womer DC West MD Krailo PS Dickman BR Pawel HE Grier K Marcus S Sailer JH Healey JP Dormans AR Weiss

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Synopsis

568 patients with localized Ewing sarcoma were randomized to receive alternating cycles of vincristine - doxorubicin - cyclophosphamide and ifosfamide-etoposide chemotherapy either every 14 or 21 days. Between cycles patients were administered filgrastim and at week 13 all patients received primary tumour treatment. The purpose of this study was to determine whether interval compression was effect...