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Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab
August 2013
Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
Lancet. 2013 May 4;381(9877):1541-50. doi: 10.1016/S0140-6736(13)60250-0. Epub 2013 Mar 18Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
326 patients with severe rheumatoid arthritis, with whom methotrexate was deemed inappropriate, were randomized to receive tocilizumab intravenously every 4 weeks plus a placebo subcutaneously every 2 weeks for 24 weeks or adalimumab subcutaneously every 2 weeks plus a placebo intravenously every 4 weeks for 24 weeks, in order to compare the safety and efficacy between the two drugs. After the 24 ...
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