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RCT
ACE Report #5081
Ace Report Cover Osteoarthritis

Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial

Lancet. 2013 May 4;381(9877):1541-50. doi: 10.1016/S0140-6736(13)60250-0. Epub 2013 Mar 18

Contributing Authors: C Gabay P Emery R van Vollenhoven A Dikranian R Alten K Pavelka M Klearman D Musselman S Agarwal J Green A Kavanaugh ADACTA Study Investigators

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Synopsis

326 patients with severe rheumatoid arthritis, with whom methotrexate was deemed inappropriate, were randomized to receive tocilizumab intravenously every 4 weeks plus a placebo subcutaneously every 2 weeks for 24 weeks or adalimumab subcutaneously every 2 weeks plus a placebo intravenously every 4 weeks for 24 weeks, in order to compare the safety and efficacy between the two drugs. After the 24 ...

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