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ACE Report #5051
Ace Report Cover Arthroplasty

Gabapentin provides no added benefit to multimodal analgesia for total knee arthroplasty


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial

Can J Anaesth. 2013 May;60(5):423-31. doi: 10.1007/s12630-013-9902-1. Epub 2013 Mar 12.

Contributing Authors: JE Paul M Nantha-Aree N Buckley J Cheng L Thabane A Tidy J DeBeer M Winemaker D Wismer D Punthakee V Avram

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OE EXCLUSIVE

Dr. J. E. Paul discusses how Gabapentin provides no added benefit to multimodal analgesia for total knee arthroplasty

Synopsis

101 total knee arthroplasty patients were randomized to evaluate gabapentin’s efficacy in reducing pain and morphine consumption. They were allocated to receive gabapentin 600 mg preoperatively followed by 200 mg every eight hours for two days or to the same regimen of placebo treatment. Evaluation after the 72-hour study period demonstrated no differences between the two treatment groups in posto...

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