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TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen
June 2013
TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty
Clin Ther. 2013 Apr;35(4):498-511. doi: 10.1016/j.clinthera.2013.03.002Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
44 patients who underwent either TKA or THA (31 of whom completed the study) were randomized to receive either a fixed dose of morphine/oxycodone, a flexible dose of morphine/oxycodone or oxycodone/acetaminophen to compare the efficacy of these analgesic treatments. Results indicated that the morphine/oxycodone flexible dose group experienced a 20% decrease in the time-weighted sum of pain intensi...
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