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ACE Report #4807
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ISASS: Use of rhBMP-2 and autologous bone in PLIF display similar clinical outcomes

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

The Effect of rhBMP-2 in one-level PLIF

Contributing Authors: J Michielsen J Sys

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


40 patients undergoing posterior lumbar interbody fusion (PLIF) were randomized to receive polyetheretherketone (PEEK) cages filled with either recombinant human bone morphogenic protein (rhBMP-2) or autologous bone to compare their clinical and radiological effects. At 24 months, the incidence of end plate resorption, osteolysis, and ectopic bone formation were frequently observed with rhBMP-2; h...

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