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Annual infusion of zoledronic acid reduces days of back pain, disability, and bed rest

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Ace Report Cover
March 2014

Annual infusion of zoledronic acid reduces days of back pain, disability, and bed rest

Vol: 3| Issue: 3| Number:9| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial

J Bone Miner Res. 2011 May;26(5):984-92. doi: 10.1002/jbmr.292

Contributing Authors:
JA Cauley D Black S Boonen SR Cummings P Mesenbrink L Palermo Z Man P Hadji IR Reid HORIZON Pivotal Fracture Group

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Synopsis

In a secondary prespecified analysis, 7736 postmenopausal women with osteoporosis were examined to evaluate the effect of once-yearly zoledronic acid on improving back pain and disability. Patients received either a single 15 minute intravenous fusion of zoledronic acid (5 mg) or placebo at baseline, 12 months, and 24 months. The assessment at 36 months indicated that zoledronic acid significantly...

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