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ACE Report #4726
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Zoledronic acid reduces number of skeletal-related events in new multiple myeloma patients


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial

Lancet Oncol. 2011 Aug;12(8):743-52. doi: 10.1016/S1470-2045(11)70157-7. Epub 2011 Jul 21

Contributing Authors: GJ Morgan JA Child WM Gregory AJ Szubert K Cocks SE Bell N Navarro-Coy MT Drayson RG Owen S Feyler AJ Ashcroft FM Ross J Byrne H Roddie C Rudin G Cook GH Jackson P Wu FE Davies National Cancer Research Institute Haematological Oncology

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Synopsis

1960 patients with multiple myeloma were randomized to undergo either intensive or non-intensive treatment. Within each treatment type patients were further randomized to receive either zoledronic acid intravenously or clodronic acid orally, in order to determine which bisphosphonate and treatment type was more effective in lowering the danger of skeletal-related events. Following assessments over...

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