AAOS: Three different regimens for prevention against thromboembolic disease
Thromboembolism Prophylaxis: Is Very Low Fixed Dose Warfarin an Equivalent Postoperative Regime?
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393 patients were randomized to compare three regimens for prevention of thromboembolic disease: Arm A (variable dose of warfarin, starting 5 mg night prior to surgery); Arm B (fondaparinux 2.5 mg daily starting 6-12 hours postoperatively); and Arm C (1 mg warfarin starting 7 days preoperatively). The 12 month assessment revealed that fixed low dose warfarin (Arm C) was not inferior to variable do...
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