ACE Report #4716
Ace Report Cover General Orthopaedics

AAOS: Three different regimens for prevention against thromboembolic disease

Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Thromboembolism Prophylaxis: Is Very Low Fixed Dose Warfarin an Equivalent Postoperative Regime?

Contributing Authors: M Bern D Wheaton DM Ward D Spitz DA Mattingly DT Reilly JV Bono CT Talmo DM Adcock

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


393 patients were randomized to compare three regimens for prevention of thromboembolic disease: Arm A (variable dose of warfarin, starting 5 mg night prior to surgery); Arm B (fondaparinux 2.5 mg daily starting 6-12 hours postoperatively); and Arm C (1 mg warfarin starting 7 days preoperatively). The 12 month assessment revealed that fixed low dose warfarin (Arm C) was not inferior to variable do...

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