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ACE Report #4400
Ace Report Cover Metabolic Disorders

Tranexamic acid reduces blood transfusion requirements during surgery

Study Type:Meta-analysis/Systematic Review
OE Level Evidence:3
Journal Level of Evidence:N/A

Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis

BMJ. 2012 May 17;344:e3054. doi: 10.1136/bmj.e3054

Contributing Authors: K Ker P Edwards P Perel H Shakur I Roberts

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In this systematic review 129 trials (consisting of 10488 participants) examining the effectiveness of tranexamic acid during surgery to a placebo or no acid were evaluated. Results displayed that tranexamic acid reduced the chances of needing a blood transfusion in surgical patients. Yet, there was not enough evidence to determine the effects of tranexamic acid on thromboembolic events and mortal...

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