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Major orthopedic surgery: Low-molecular-weight heparins vs other anticoagulants
August 2013
Major orthopedic surgery: Low-molecular-weight heparins vs other anticoagulants
Study Type:Meta-analysis/Systematic Review
OE Level Evidence:2
Journal Level of Evidence:N/A
Comparative Effectiveness of Low-Molecular-Weight Heparins versus Other Anticoagulants in Major Orthopedic Surgery: A Systematic Review and Meta-analysis
Pharmacotherapy. 2012 Sep;32(9):799-808. doi: 10.1002/j.1875-9114.2012.01106.x. Epub 2012 Jun 28Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
This meta-analysis and systematic review included 37 studies comparing low molecular-weight heparins (LMWHs) to other anticoagulants in patients undergoing major orthopedic surgery. The results indicated that LMWHs were more effective and also led to fewer cases of bleeding than unfractionated heparins. LMWHs led to fewer cases of deep vein thrombosis events than vitamin K antagonists, but resulte...
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