3 doses of tranexamic acid more effective regimen in TKA

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Most Effective Regimen of Tranexamic Acid in Knee Arthroplasty. A Prospective Randomized Controlled Study in 240 Patients

Clin Orthop Relat Res. 2012 Sep;470(9):2605-12. doi: 10.1007/s11999-012-2310-y. Epub 2012 Mar 15.

Contributing Authors: Rajesh N Maniar Gaurav Kumar Tushar Singhi Ravi Mohan Nayak Parul R Maniar

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Synopsis

206 patients undergoing total knee arthroplasty were randomized to 6 different groups to determine the ideal dosage and mode of treatment for tranexamic acid. Patients were to receive an intraoperative dose of tranexamic acid given before tourniquet deflation (group 1), an intraoperative dose of tranexamic acid with an additional preoperative dose (group 2), an intraoperative dose of tranexamic ac...