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RCT
ACE Report #3560
Ace Report Cover Arthroplasty

Revision THR: Bisphosphonate rinse of morcellised bone grafts prevents bone resorption


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption. A prospective randomised double-blinded study.

J Bone Joint Surg Br. 2006 Aug;88(8):993-6

Contributing Authors: U Kesteris P Aspenberg

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Synopsis

15 patients who were undergoing revision total hip replacement were randomized to receive a morcellised compacted bone allograft rinsed in either a bisphosphonate solution or in a saline solution. After 3 months, the bone mineral density of the saline patients decreased significantly, and then levelled off. In contrast, bone density increased in the first 3 months after surgery before levelling o...

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