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Celecoxib and aceclofenac reduce COX-2 and mPEGS-1 expression in osteoarthritic patients
April 2013
Celecoxib and aceclofenac reduce COX-2 and mPEGS-1 expression in osteoarthritic patients
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis
Osteoarthritis Cartilage. 2008 Dec;16(12):1484-93. Epub 2008 Jun 10Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
30 patients with osteoarthritis (OA) of the knee, scheduled to undergo total knee replacement surgery, were randomized to either receive treatment with either Celecoxib or Aceclofenac (NSAIDs). Patients who did not want to be treated served as a non-randomized comparison group. The results indicated that both Celecoxib and Aceclofenac (NSAIDs) were effective in reducing gene expression for COX-2, ...
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