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rhBPM-2 with allograft effective for reconstruction of diaphyseal tibial fractures

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Ace Report Cover
August 2013

rhBPM-2 with allograft effective for reconstruction of diaphyseal tibial fractures

Vol: 2| Issue: 7| Number:510| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:2

Recombinant Human BMP-2 and Allograft Compared with Autogenous Bone Graft for Reconstruction of Diaphyseal Tibial Fractures with Cortical Defects

J Bone Joint Surg Am. 2006 Jul;88(7):1431-41.

Contributing Authors:
Alan L Jones Robert W Bucholz Michael J Bosse Sohail K Mirza Thomas R Lyon Lawrence X Webb Andrew N Pollak Jane Davis Golden Alexandre Valentin-Opran

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Synopsis

30 patients with a tibial diaphyseal fracture and a residual cortical defect were randomized to receive either an autogeneous bone graft or an allograft with recombinant human bone morphogenetic protein-2 (rhBMP-2) to reconstruct the tibial defect. Surgical morbidity, clinical and radiographic signs of healing, and impact on health related quality of life (Short Musculoskeletal Function Assessment...

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