TKR: blood conservation similar between one and two injections of tranexamic acid
The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective?J Bone Joint Surg Br. 2012 Jul;94(7):932-6
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151 patients undergoing unilateral minimally invasive total knee replacement (TKR) were randomized to receive either one-dose of tranexamic acid (TEA) (10 mg/kg), two-doses TEA (10 mg/kg), or a placebo. The primary outcome was total blood loss, measured by maximum loss of haemoglobin (Total blood loss = (Total blood volume x [change in haemoglobin level / mean haemoglobin]) + volume transfused) ...
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