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TKR: blood conservation similar between one and two injections of tranexamic acid

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Ace Report Cover
August 2013

TKR: blood conservation similar between one and two injections of tranexamic acid

Vol: 2| Issue: 7| Number:253| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective?

J Bone Joint Surg Br. 2012 Jul;94(7):932-6

Contributing Authors:
PC Lin CH Hsu CC Huang WS Chen JW Wang

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Synopsis

151 patients undergoing unilateral minimally invasive total knee replacement (TKR) were randomized to receive either one-dose of tranexamic acid (TEA) (10 mg/kg), two-doses TEA (10 mg/kg), or a placebo. The primary outcome was total blood loss, measured by maximum loss of haemoglobin (Total blood loss = (Total blood volume x [change in haemoglobin level / mean haemoglobin]) + volume transfused) ...

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