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TKR: blood conservation similar between one and two injections of tranexamic acid
August 2013
TKR: blood conservation similar between one and two injections of tranexamic acid
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective?
J Bone Joint Surg Br. 2012 Jul;94(7):932-6Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
151 patients undergoing unilateral minimally invasive total knee replacement (TKR) were randomized to receive either one-dose of tranexamic acid (TEA) (10 mg/kg), two-doses TEA (10 mg/kg), or a placebo. The primary outcome was total blood loss, measured by maximum loss of haemoglobin (Total blood loss = (Total blood volume x [change in haemoglobin level / mean haemoglobin]) + volume transfused) ...
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