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Biochemical markers of bone and cartilige degradation associated with progression of OA
March 2013
Biochemical markers of bone and cartilige degradation associated with progression of OA
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: The Knee Osteoarthritis Structural Arthritis randomized clinical trial
Osteoarthritis Cartilage. 2008 Jun;16(6):660-6. Epub 2007 Nov 13.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
2483 patients were recruited to two parallel studies in North America (NA) and Europe (EU) to assess the effect of the structure modifying anti-OA drug, risedronate, on bone and cartilage degradation markers and radiological progression of OA. At 6 months, there was a dose-dependent induced reduction in markers of cartilage and bone degradation that was maintained until 24 months follow-up. Radiol...
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