To unlock this feature and to subscribe to our weekly evidence emails, please create a FREE orthoEvidence account.

SIGNUP

Already Have an Account?

Loading...
Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Ace Report Cover

Tibolone reduces fracture risk in osteoporotic women but increases stroke risk

Download
Share
Reprints
Cite This
About
+ Favorites
Share
Reprints
Cite This
About
+ Favorites
Ace Report Cover
April 2013

Tibolone reduces fracture risk in osteoporotic women but increases stroke risk

Vol: 2| Issue: 3| Number:43| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

The Effects of Tibolone in Older Postmenopausal Women

N Engl J Med. 2008 Aug 14;359(7):697-708

Contributing Authors:
SR Cummings B Ettinger PD Delmas P Kenemans V Stathopoulos P Verweij M Mol-Arts L Kloosterboer L Mosca C Christiansen J Bilezikian EM Kerzberg S Johnson J Zanchetta DE Grobbee W Seifert R Eastell

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here

Synopsis

4538 post-menopausal women (age 60-85) with low bone mineral density were randomized to either receive a daily dose of Tibolone (1.25mg) or an identical placebo. The results indicated that the use of tibolone resulted in a reduced risk for developing vertebral and non-vertebral fractures, invasive breast cancer as well as colon cancer. However, it is important to note that tibolone did increase th...

CME Image

Did you know that you’re eligible to earn 0.5 CME credits for reading this report!

LEARN MORE

Join the Conversation

Please Login or Join to leave comments.

Learn about our AI Driven
High Impact Search Feature

High Impact Icon

The OE High Impact metric uses AI to determine the impact a study will have by considering the content of the article itself. Built using the latest advances of natural language processing techniques. OE High Impact predicts an article’s future number of citations than impact factor alone.

Continue