Tibolone reduces fracture risk in osteoporotic women but increases stroke risk
The Effects of Tibolone in Older Postmenopausal WomenN Engl J Med. 2008 Aug 14;359(7):697-708
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4538 post-menopausal women (age 60-85) with low bone mineral density were randomized to either receive a daily dose of Tibolone (1.25mg) or an identical placebo. The results indicated that the use of tibolone resulted in a reduced risk for developing vertebral and non-vertebral fractures, invasive breast cancer as well as colon cancer. However, it is important to note that tibolone did increase th...
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