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Tibolone reduces fracture risk in osteoporotic women but increases stroke risk
April 2013
Tibolone reduces fracture risk in osteoporotic women but increases stroke risk
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
The Effects of Tibolone in Older Postmenopausal Women
N Engl J Med. 2008 Aug 14;359(7):697-708Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
4538 post-menopausal women (age 60-85) with low bone mineral density were randomized to either receive a daily dose of Tibolone (1.25mg) or an identical placebo. The results indicated that the use of tibolone resulted in a reduced risk for developing vertebral and non-vertebral fractures, invasive breast cancer as well as colon cancer. However, it is important to note that tibolone did increase th...
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