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ACE Report #2828
Ace Report Cover Pediatric Orthopaedics

Juvenile RA: Fewer disease flares with Adalimumab (TNF Antibody)

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Adalimumab with or without Methotrexate in Juvenile Rheumatoid Arthritis

N Engl J Med. 2008 Aug 21;359(8):810-20

Contributing Authors: DJ Lovell N Ruperto S Goodman A Reiff L Jung K Jarosova D Nemcova R Mouy C Sandborg J Bohnsack D Elewaut I Foeldvari V Gerloni J Rovensky K Minden RK Vehe LW Weiner G Horneff HI Huppertz NY Olson JR Medich R Carcereri-De-Prati McIlra

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This was a three part study designed to assess the effectiveness of Adalimumab, a fully human monoclonal anti-TNF antibody, in the treatment of juvenile rheumatoid arthritis. The study consisted of an open-label lead-in phase (where patients were stratified according to methotrexate use), a double-blind withdrawal phase (following the 16 week lead-in phase, patients with an ACR Pedi 30 response we...

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