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RA: Addition of etanercept to methotrexate increases remission rates

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Ace Report Cover
April 2013

RA: Addition of etanercept to methotrexate increases remission rates

Vol: 2| Issue: 3| Number:36| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): A randomised, double-blind, parallel treatment trial

Lancet. 2008 Aug 2;372(9636):375-82. Epub 2008 Jul 16

Contributing Authors:
P Emery FC Breedveld S Hall P Durez DJ Chang D Robertson A Singh RD Pedersen AS Koenig B Freundlich

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Synopsis

542 patients with adult-onset rheumatoid arthritis were randomized to either receive a combination treatment of both etanercept and methotrexate, or just treatment with methotrexate. The results at 1 year indicated that the combination of etanercept and methotrexate resulted in high remission rates and was effective in arresting radiographic progression of joint damage.

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