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OP-1 use has equivalent outcomes as bone autograft in spinal fusion applications
March 2013
OP-1 use has equivalent outcomes as bone autograft in spinal fusion applications
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: Minimum 4-year follow-up of a pilot study
Spine J. 2008 May-Jun;8(3):457-65. Epub 2007 May 25.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
36 patients undergoing decompressive laminectomy and single-level uninstrumented fusion were randomized to either a OP-1 putty or autogenous iliac crest bone graft for degenerative spondylolisthesis and symptomatic spinal stenosis. The use of OP-1 had comparable rates of radiographic fusion, clinical improvement, and overall success rates to the autograft controls at 48 months after surgery.
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