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Wound complication and infection rates after medicated lavage for periprosthetic joint infections
December 2025
Wound complication and infection rates after medicated lavage for periprosthetic joint infections
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The Three-Month Wound Complication and Infection Rates After Vancomycin Powder and Dilute Povidone-Iodine Lavage for Infection Prophylaxis in High-Risk Total Joint Arthroplasty: A Multicenter Randomized Controlled Trial.
J Arthroplasty. 2025 01-Sep;():. 10.1016/j.arth.2025.04.084Synopsis
In this large, prospective, multicenter, open-label randomized controlled trial, 1901 high-risk patients undergoing primary total joint arthroplasty were randomized across 17 U.S. centers into four groups: vancomycin powder alone, dilute povidone-iodine lavage alone, combined vancomycin–povidone-iodine protocol, or saline control. The cohort included 821 total hip arthroplasties (THA) and 1080 tot...
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