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Comparing Remimazolam and Dexmedetomidine in Older Patients Under Lower Extremity Orthopedic Surgery
December 2025
Comparing Remimazolam and Dexmedetomidine in Older Patients Under Lower Extremity Orthopedic Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Comparison of Remimazolam versus Dexmedetomidine on Hemodynamics in Older Patients Under Lower Extremity Orthopedic Surgery with Spinal Anesthesia: A Randomized Controlled Trial.
Drug Des Devel Ther. 2025 01-Jul;():. 10.2147/DDDT.S504371Synopsis
One hundred twenty-six older adults undergoing lower-extremity orthopedic surgery under spinal anesthesia were randomized in a single-blind, parallel-group trial to receive intraoperative sedation with either remimazolam or dexmedetomidine. All patients received standardized spinal anesthesia with hyperbaric bupivacaine. The primary outcome was the incidence of hemodynamic fluctuations, specifical...
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