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Specific and Nonspecific Brain Mechanisms of Acupuncture Analgesia in Knee Osteoarthritis
October 2025
Specific and Nonspecific Brain Mechanisms of Acupuncture Analgesia in Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of acupuncture treatment for patients with knee osteoarthritis on brain fluctuation amplitude and functional connectivity: a randomized three-armed fMRI study.
BMC Complement Med Ther . 2025 Jul 9;25(1):244.Synopsis
Ninety patients with knee osteoarthritis were randomized to acupuncture (n=30), sham acupuncture (n=30), or waiting list (n=30). Patients received twelve 30-minute sessions over 4 weeks. The primary outcome was response (≥2-point NRS reduction at week 4). Secondary outcomes included changes in NRS, WOMAC, STAI-S, and fMRI metrics: ALFF (resting-state spontaneous activity) and seed-based functional...
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