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Single Low-Dose Dexamethasone Improves Early Pain and Recovery After Total Knee Arthroplasty
October 2025
Single Low-Dose Dexamethasone Improves Early Pain and Recovery After Total Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
A Single Preoperative Low Dose of Dexamethasone Is Efficacious in Improving Early Postoperative Pain, Function, Nausea, and Vomiting After Primary Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
J Arthroplasty . 2025 Jul;40(7):1719-1725.Synopsis
Eighty-six patients with end-stage osteoarthritis undergoing unilateral primary Total Knee Arthroplasty (TKA) were randomized to receive dexamethasone 8 mg IV once after anesthesia (n=43) or placebo saline (n=43). The primary outcome was postoperative pain (VAS) at rest and with walking. Secondary outcomes included postoperative nausea and vomiting (VAS for nausea and vomiting episodes), Time Up a...
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