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Methotrexate for Pain and Function in Osteoarthritis
August 2025
Methotrexate for Pain and Function in Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy and safety of methotrexate in osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.
Osteoarthritis Cartilage . 2025 Jun;33(6):680-691.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Six randomized controlled trials including 602 patients with knee or hand osteoarthritis were included in this systematic review and meta-analysis comparing methotrexate with placebo (five trials) or glucosamine (one trial). Pooled outcomes of interest included pain, physical function, quality of life, adverse events, and osteoarthritis-related biochemical and imaging biomarkers. Methotrexate sign...
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