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The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis
August 2025
The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The Effect of Corticosteroid Doses on Pain in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.
Musculoskeletal Care . 2025 Jun;23(2):e70121.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Twelve randomized controlled trials including 1,125 patients with knee osteoarthritis were included in this systematic review, with 11 studies (n = 1,005) analyzed in the meta-analysis comparing low (<40 mg), usual (40 mg), and high (>40 mg methylprednisolone-equivalent) intra-articular corticosteroid injections versus normal saline. Outcomes of interest were pain reduction at very short term (1–3...
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