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Pre-Emptive vs. Postincision Acetaminophen for Postoperative Pain
August 2025
Pre-Emptive vs. Postincision Acetaminophen for Postoperative Pain
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Pre-Emptive Acetaminophen for Postoperative Pain (PAPP): An Updated Meta-Analysis.
J Perianesth Nurs . 2025 Apr;40(2):415-421.e4.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Twelve studies including 845 adult surgical patients were included in this systematic review and meta-analysis comparing pre-emptive intravenous acetaminophen with postincision acetaminophen. Pooled outcomes of interest included 24-hour morphine consumption, postoperative vomiting, time to analgesic request, pain scores at 6 and 24 hours, and pruritus. Pre-emptive acetaminophen significantly reduc...
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