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Combining Exercise Training And Testosterone Therapy In Older Women After Hip Fracture

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Ace Report Cover
July 2025

Combining Exercise Training And Testosterone Therapy In Older Women After Hip Fracture

Vol: 307| Issue: 7| Number:14| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial.

JAMA Netw Open . 2025 May 1;8(5):e2510512.

Contributing Authors:
EF Binder JM Bartley SD Berry PM Doré SR Fisher RH Fortinsky C Guild DP Kiel GA Kuchel RL Marcus CM McDonough KM Monroe DL Orwig RA Paluch D Reeds J Stevens-Lapsley E Volpi KB Schechtman JS Magaziner

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Synopsis

One hundred twenty-nine women with mobility impairment following hip fracture were randomized to receive supervised high-intensity exercise plus topical testosterone gel (n=55), exercise plus placebo gel (n=54), or enhanced usual care (n=20). The primary outcome was change in 6-minute walking distance (6MWD) from baseline to 24 weeks. Secondary outcomes included changes in Short Physical Performan...

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