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COA 2025: Cannabidiol to Prevent Persistent Post-Surgical Pain Following Total Knee Arthroplasty
June 2025
COA 2025: Cannabidiol to Prevent Persistent Post-Surgical Pain Following Total Knee Arthroplasty
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A
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CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Synopsis
Thirty-nine patients undergoing total knee arthroplasty were randomized to receive either a CBD-dominant oral cannabis formulation (n≈20) or placebo (n≈19) alongside standard care, beginning 4 weeks preoperatively and continuing for up to 12 weeks postoperatively. The primary outcome was feasibility of trial conduct. Secondary exploratory outcomes included persistent post-surgical pain (PPSP), opi...
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