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Intranasal Insulin Reduces Delirium in Elderly Joint Surgery Patients
June 2025
Intranasal Insulin Reduces Delirium in Elderly Joint Surgery Patients
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial.
Drug Des Devel Ther . 2025 Feb 1:19:759-769.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred ninety-five older patients undergoing elective joint replacement were randomized to receive either 40 IU of intranasal insulin twice daily (n=96) or placebo (n=99) for 8 days surrounding surgery. The primary outcome was the incidence and severity of postoperative delirium (POD) assessed using the Confusion Assessment Method and Delirium Rating Scale-98 over the first 5 days postoperati...
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